Organ preservation for clinical T2N0 distal rectal cancer using neoadjuvant chemoradiotherapy and local excision (ACOSOG Z6041): results of an open-label, single-arm, multi-institutional, phase 2 trial
نویسندگان
چکیده
Memorial Sloan Kettering Cancer Center, New York, NY, USA (Prof J Garcia-Aguilar MD, O S Chow MD, P B Lynn MD); Mayo Clinic, Rochester, MN, USA (L A Renfro PhD, Q Shi PhD, X W Carrero BBA, Prof B G Wolff MD); Oregon Health and Science University, Portland, OR, USA (Prof C R Thomas Jr MD); Vanderbilt University Medical Center, Nashville, TN, USA (E Chan MD); University of Vermont, Burlington, VT, USA (Prof P A Cataldo MD); Tampa General Hospital, Tampa, FL, USA (Prof J E Marcet MD); University of Pittsburgh Medical Center, Pittsburgh, PA, USA (D S Medich MD); St Francis Hospital, Tulsa, OK, USA (C S Johnson MD); John Muir Medical Center, Concord, CA, USA (S C Oommen MD); University of California, Irvine, Irvine, CA, USA (A Pigazzi MD); Holy Family Hospital, Spokane, WA, USA (S M McNevin MD); Hialeah Hospital, Hialeah, FL, USA (R K Pons MD); and Brigham and Women’s Hospital, Boston, MA, USA (Prof R Bleday MD)
منابع مشابه
Organ Preservation for Clinical T2n0 Distal Rectal Cancer Using Neoadjuvant Chemoradiotherapy and Local Excision: Results of a Multicenter Phase 2 Study
BACKGROUND Local excision is an organ-preserving treatment alternative to transabdominal resection for patients with stage I rectal cancer. However, local excision alone is associated with a high risk of local recurrence and inferior survival compared with transabdominal rectal resection. We investigated the oncological and functional outcomes of neoadjuvant chemoradiotherapy and local excision...
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